Targovax, in partnership with Merck & Co., will soon be opening a mesothelioma clinical trial combining ONCOS-102 with Keytruda, known generically as pembrolizumab. Both companies believe a combination of the two different types of immunotherapy could spark an effective synergy.

A Randomised Phase II Open-label Study With a Phase Ib Safety lead-in Cohort of ONCOS-102, an Immune-priming GM-CSF Coding Oncolytic Adenovirus, and Pemetrexed/Cisplatin in Patients With Unresectable Malignant Pleural Mesothelioma - Full Text View.

The Norwegian cancer therapeutic company now has an advantage towards getting full approval. Targovax, the maker of the treatment ONCOS-102, announced promising clinical study results at the 21-month check-up. These successes are follow-ups to the reported outcomes from six, nine, 12 and 15 months ago, when the company offered hope for late-stage pleural mesothelioma patients. The trial is an open-label, parallel group, multicentre trial that will recruit a total of 30 patients with malignant pleural mesothelioma. The trial will be conducted in 2 phases: a non-randomised safety phase and a randomised phase. The safety phase will consist of a lead-in cohort of 6 patients treated with ONCOS 102 and pemetrexed/cisplatin.

Targovax mesothelioma

Targovax’s lead product, ONCOS-102, is an oncolytic virus designed to target and eliminate hard-to-treat tumors in patients with mesothelioma, melanoma, and peritoneal malignancies. The company announced last week the first set of clinical results from the randomized phase I/II trial of ONCOS-102 in combination with standard chemotherapy . 2021-02-23 · Continued survival benefit in Targovax's ONCOS-102 trial in mesothelioma at the 21-month follow-up Median Overall Survival (mOS) has still not been met for randomized first-line patients receiving A Randomised Phase II Open-label Study With a Phase Ib Safety lead-in Cohort of ONCOS-102, an Immune-priming GM-CSF Coding Oncolytic Adenovirus, and Pemetrexed/Cisplatin in Patients With Unresectable Malignant Pleural Mesothelioma - Full Text View. Targovax ASA (OSE: TRVX), a clinical stage immuno-oncology company developing immune activators to target hard-to-treat solid tumors, today announces 21-month follow-up data from the randomized Targovax is an immunoncology company headquartered in Oslo, Norway, developing an oncolytic virus platform, ONCOS. ONCOS-102 is prioritised in several indications including mesothelioma and melanoma. Targovax is also working on next-generation oncolytic viruses in its preclinical R&D pipeline. The mesothelioma study we’ve been waiting for is finally going to happen.

PR Newswire. (2019, May 8).

Targovax’s ONCOS-102 mesothelioma 12-month data demonstrate broad immune activation linked to clinical benefit and the company announces a new collaboration with Merck. Targovax has released 12-month efficacy and immunological data from the randomized phase I/II trial of ONCOS-102 in combination with standard of care chemotherapy in malignant pleural mesothelioma (MPM).

3 days ago Immunotherapy treatment for mesothelioma patients is becoming more and A Norwegian biotech firm, Targovax, has also had early signs of See insights on Targovax including office locations, competitors, revenue, and ONCOS-102 that is in Phase I/II study for the treatment of mesothelioma, as well ONCOS 102 is being developed by Targovax (previously Oncos Therapeutics), for the treatment of cancers, including malignant pleural mesothelioma, Malignant pleural mesothelioma (MPM) is an aggressive inflammatory cancer initiated in MPM, Targovax has begun a phase I/II trial investigating the safety, Targovax loses prostate cancer partner after enrollment struggles least 18.2 months for first-line mesothelioma patients receiving the drug plus chemotherapy. Study on Mesothelioma Survival Confirms Chemo Helps · December 20, 2016. You're likely to Targovax Keeps Working on Mesothelioma Drug ONCOS-102. Jun 13, 2018 ONCOS-102 will be developed in mesothelioma as launch indication, In light of new Folfirinox data, Targovax and its clinical advisors will Feb 26, 2015 the treatment of malignant mesothelioma.

Targovax ASA (0RIS) · Targovax announces completion of safety lead-in and preliminary immune activation data in ONCOS-102 trial in mesothelioma.

PRESS RELEASE PR Newswire . May. 4, 2020, 01:20 AM. OSLO, Norway, May 4, 2020 /PRNewswire/ -- Targovax … Targovax, a leading immuno-oncology therapy organization has seen great results in a new clinical trial for mesothelioma patients.

Targovax announces collaboration to evaluate ONCOS-102 in combination with KEYTRUDA in mesothelioma. Targovax’s ONCOS-102 mesothelioma 12-month data demonstrate broad immune activation linked to clinical benefit and the company announces a new collaboration with Merck. Targovax has released 12-month efficacy and immunological data from the randomized phase I/II trial of ONCOS-102 in combination with standard of care chemotherapy in malignant pleural mesothelioma (MPM). Oslo, Norway, 22 June 2020 - Targovax ASA (OSE: TRVX), a clinical stage immuno-oncology company developing oncolytic viruses to target hard-to-treat solid tumors, today releases 12-month efficacy and immunological data from the randomized phase I/II trial of ONCOS-102 in combination with standard of care chemotherapy in malignant pleural mesothelioma (MPM). Oslo, Norway, 21 January 2020 – Targovax ASA (OSE: TRVX), a clinical stage immuno-oncology company developing oncolytic viruses to target hard-to-treat solid tumors, today announces the first set of clinical results from the randomized phase I/II trial of ONCOS-102 in combination with standard of care chemotherapy in malignant pleural mesothelioma (MPM). 2021-04-22 · ONCOS-102 and FDA Approval for Mesothelioma.
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Targovax's lead product candidate, ONCOS-102, is a genetically modified Targovax’s lead product, ONCOS-102, is an oncolytic virus designed to target and eliminate hard-to-treat tumors in patients with mesothelioma, melanoma, and peritoneal malignancies. The company announced last week the first set of clinical results from the randomized phase I/II trial of ONCOS-102 in combination with standard chemotherapy . Targovax says they plan to focus on untreated mesothelioma patients in a future trial.

Targovax, the maker of the treatment ONCOS-102, announced promising clinical study results at the 21-month check-up.
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5 Nov 2020 Hegnar Media - Targovax ASA Webcast Q3 2020. Topics. Colorectal. Finance. Introduction and highlights. Melanoma. Mesothelioma. Q&A

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TARGOVAX'S ONCOS-102 MESOTHELIOMA 12-MONTH DATA POWERFULLY DEMONSTRATE BROAD IMMUNE ACTIVATION LINKED TO CLINICAL

Part of the University of Maryland Marlene and malignant pleural mesothelioma (MPM). -data-for-oncos-102-in-mesothelioma/)). same chemotherapy treatment[1]. efficacy in this highly ONCOS-102 is currently being tested in mesothelioma, melanoma and peritoneal malignancies and has already shown promising clinical results both as Targovax demonstrates encouraging survival data for ONCOS-102 in mesothelioma. ONCOS-102-treated patients show broad and powerful Continued survival benefit in Targovax's ONCOS-102 trial in mesothelioma at the 21-month follow-up. Targovax.

2021-03-02 · FDA Accelerates Review of Immunotherapy Drug for Mesothelioma. Biotech company Targovax recently announced its clinical drug ONCOS-102 was given FDA Fast Track designation for pleural mesothelioma. This means the FDA will speed up the review process of ONCOS-102. The FDA Fast Tracks an emerging treatment if it meets two criteria: Targovax appears to have a clear plan to advance ONCOS-102 testing in mesothelioma to late-stage development. While, understandably, the concrete trial design and timelines are not yet available, the likely positioning of ONCOS-102 and the preliminary study plan are clear (Exhibit 5). Targovax, the manufacturer of an oncolytic adenovirus called ONCOS-102, will pair its therapy with Keytruda in a study explicitly for mesothelioma. The trial will involve all cell types and include locations in the United States.